Tag Archives: disease

Vaccine Update: The Impact Of The Moderna Vaccine (Beyond COVID-19)

Sometimes, it takes a terrible global crisis to spurn huge leaps in technology. World War II was arguably the greatest crisis of the modern era, but it helps advance some of the greatest technological leaps in history. We can argue whether those advances were worth all the death and destruction, but there’s no denying that our world wouldn’t be the same without them.

The COVID-19 pandemic isn’t on the same level as World War II, but it is, by most measures, the greatest crisis the world has faced in the past 50 years. It hasn’t just caused hundreds of thousands of deaths and immeasurable amounts of suffering. It has completely disrupted this big, interconnected world that we’ve come to depend on.

We’ve all lost something in this pandemic. Beyond the loved ones who have perished, our entire sense of security and hope has been shattered. We now realize just how vulnerable we were and how inevitable this was. As bad as it is, there is some good coming out of it.

Usually, a crisis like this helps break down the barriers that divided us and hindered progress, technological or otherwise. Never before has the world been more united or engaged in a singular effort. Before 2020, we probably didn’t know much about vaccines or vaccine research. We just knew that Jenny McCarthy tried to be relevant again by protesting them.

That’s changing now. The global effort to create a vaccine for this terrible disease has been watched and agonized over for months. Most recently, we got a much-needed glimmer of hope from Pfizer, who reported that their vaccine is 90 percent effective. I celebrated this news like everyone else.

Then, we got an even greater glimmer of hope from the other vaccine front-runner by Moderna. Not only is their vaccine in the final phase of testing, like Pfizer. It’s even more effective and promises to be easier to store and distribute.

CNN: Moderna’s coronavirus vaccine is 94.5% effective, according to company data

The Moderna vaccine is 94.5% effective against coronavirus, according to early data released Monday by the company, making it the second vaccine in the United States to have a stunningly high success rate.

“These are obviously very exciting results,” said Dr. Anthony Fauci, the nation’s top infectious disease doctor. “It’s just as good as it gets — 94.5% is truly outstanding.”

Moderna heard its results on a call Sunday afternoon with members of the Data Safety and Monitoring Board, an independent panel analyzing Moderna’s clinical trial data.

This is objectively great news in a year when we’ve had precious little of it. These two vaccines may very well be the one-two punch we need to end the COVID-19 pandemic and return to some semblance of normalcy. I would still like to go to a movie theater or baseball game at some point in 2021. These vaccines may make that possible.

However, I’d like to take a moment to speculate beyond this terrible pandemic that has uprooted so many lives. I know that’s not easy to do when the crisis is still very relevant and inflicting plenty of suffering. I still think it’s worth attempting, if only to imagine the better world that emerges from this mess.

That’s because both these vaccines aren’t like your typical flu shots. For one, flu shots aren’t nearly as effective as what Pfizer and Moderna reported. According to the CDC, you’re average flu shot is between 40 and 60 percent effective. That’s still important because the flu can be deadly. Anything you do to reduce it can only further public health, in general.

The problem is the flu shot, and most vaccines like it, are based on old technology. At their most basic, they take a non-infectious or weakened strain of a pathogen and use it to amp up your body’s immunity. It’s crude, but it works. Literally nothing has saved more lives than vaccines.

The problem is that vaccines are notoriously hard to develop. They take a long time to test and an even longer time to approve. Until this pandemic, there just wasn’t much incentive to improve on that process. Now, after these past 8 months, the incentive couldn’t have been greater.

That’s what sped up the development of mRNA vaccines, the technology behind both Pfizer and Moderna. It was reported on as far back as 2018. While this technology isn’t completely new, it has never been developed beyond a certain point. There just wasn’t any incentive to do so. A global crisis changed that.

Very simply, an mRNA vaccine does one better on traditional vaccines by using RNA to develop immunity. It’s not as easy as it sounds. To develop that immunity, it has encode itself with just the right antigen. That way, the antibodies it creates can attack the desired pathogen.

In the case of COVID-19, the mRNA vaccine attacks the distinct spike protein the virus uses to attach to host cells. It’s like a missile targeting a specific individual in a large crowd by locking onto the distinct hat they wear.

This approach has the potential to be much more effective at generating immunity to a particular disease. Instead of trying to mimic a virus, it just gives the immune system the necessary software it needs to do the work. It could potentially revolutionize the way we treat and prevent diseases.

For years, certain viruses like the flu and HIV have confounded efforts to develop a vaccine. Beyond the problems I listed earlier with regards to testing, the difficulty of creating a particular immune response to a particular antigen is very difficult. These viruses mutate and change all the time. With COVID, vaccines do have an advantage because they have a distinct feature.

The challenge for future vaccines against future pandemics is quickly uncovering a particular antigen that the mRNA can be coded for. In theory, all you would have to do is find the one key antigen that’s common to every strain of the virus. While viruses like the flu are notoriously diverse, they can only change so much.

It’s akin to trying to identify an army of spies in a large crowd. They may all look different on the outside, but if they all have the same socks, then that’s what you code for. With some refinements, an mRNA vaccine can stop a pandemic in its tracks before it ever gets beyond a certain point.

That assumes we’ll continue to refine this technology after the COVID-19 pandemic has passed. I certainly hope that’s the case. This year has traumatized entire generations with how much pain and suffering it has inflicted. I sincerely hope that gives plenty of motivation to develop technology like this. That way, we never have to endure a disruption like this again.

To all those who helped develop this technology and these two vaccines, I hope you appreciate the impact you’ll make with this technology. The number of lives they could save is incalculable. Future generations may not remember your names, but they will be forever grateful for this wondrous gift you’ve given them.

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Apologies For A Post That Did NOT Age Well

We all say, do, or write things that don’t age well and it’s not just because of cancel culture. Sometimes, you just do things that turn out to be dead wrong. It happens. It’s distressing, uncomfortable, and frustrating. It’s also unavoidable. We’re all fallible humans. We’re going to be wrong every now and then. It’s just a matter of degree.

To that end, I’d like to admit my own major error. I probably could’ve just casually ignored this, but I think it’s better that I confront this now rather than later. Back in late February, I wrote something about the coronavirus. Without getting into every detail on that piece, I’ll just say this. I was wrong. I was very, very wrong and I apologize.

For the full story and context, here’s a link and an excerpt.

A (Hopeful) Perspective On The Coronavirus

There’s another perspective worth considering when following the news of the coronavirus. Unlike the devastating plagues of the past, humanity has developed a decent infrastructure for medicine, technology, and research. Granted, it took us centuries of trial, error, and mass death and there’s still plenty of room for improvement, but that system is there. It’s better than nothing. Just ask Medieval Europe.

That system is already doing its job in combating the virus. Already, researchers at the University of Texas in Austin have mapped out critical portions of the virus. That sort of thing couldn’t have been done this quickly or at all just 30 years ago. This data is critical for the development of treatments and, ultimately, a vaccine.

The fact that this happened so quickly after the outbreak is something the news hasn’t reported on. Even if treatments develop and the virus is contained, as we’ve seen with other recent outbreaks, it probably won’t be a huge story within the ever-changing news cycle.

It almost seems quaint. I come off as so hopeful that this isn’t going to be a major issue. This isn’t going to utterly break the world and turn 2020 into a devolving mess of frustration, misery, and outrage. Usually, my optimism helps me navigate tough times, but optimism doesn’t do squat against a global pandemic.

This isn’t a renegade hashtag.

This isn’t some juicy celebrity scandal.

This isn’t even some horrific terrorist attack that brings out the best and worst and people.

Global pandemics are different. They don’t give a damn about politics, economic trends, social trends, or when baseball season is supposed to start. It’s a mindless disease and it’s killing us. Even at my most cynical, I never imagined it could cause this much suffering and death. Now, as a fresh spike in cases is starting to take hold, what I wrote in February only seems more foolish.

As such, I sincerely apologize. I was wrong. I had no idea it was going to get this bad. If you read that article and took comfort in it at the time, I’m very sorry.

I’m still trying to cling to some semblance of optimism. I do believe that this crisis, like many others before it, will pass. It’s just going to get a lot worse before it gets better.

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Filed under Current Events, Jack Fisher's Insights, media issues, technology

PSA: Wear A Mask (And Wear Condoms)

Under normal circumstances, we shouldn’t need to remind people to be safe and responsible.

Under normal circumstances, we shouldn’t have to explain why certain safety measures are worth the inconvenience.

These are not normal circumstances. Let’s not pretend otherwise.

We’re in the midst of a global pandemic that has killed hundreds of thousands of people. Thousands more are likely to die, even after we develop an effective treatment. This is serious. There’s a time for debating the balance between public safety and personal freedom. This is not it. Viruses don’t give a damn about politics, borders, race, economic trends, or who gets cast in a Disney movie.

With that being said, I have a simple statement/public service announcement.

Wear a mask when you go out in public.

Yes, it’s not convenient or comfortable.

Yes, it’s not stylish or flattering.

Yes, it’s infuriating that we’ve let it get this bad.

It’s still a simple, sensitive recourse that can help combat this crisis. The science is clear now . Wearing a mask helps in multiple ways. For someone who has the virus, it keeps them from spewing the droplets into the air around them, thus protecting others. For someone who doesn’t have the virus, it prevents those droplets from getting into your nose and mouth.

It’s essentially a double barrier. You protect yourself and you protect others. It doesn’t require a prescription or some overpriced medicine. Most people can make an effective mask with the right materials and a sewing machine. It’s not perfect, but it’s better than nothing. It doesn’t eliminate risk, but it does reduce it considerably.

It’s not unlike condoms, another protective measure that gets caught up in politics, albeit for different reasons. Like masks for your genitals, they do the same thing. They protect your body from outside invaders. It can be just as be as inconvenient and frustrating, but it beats the alternative of getting sick or pregnant. In fact, so long as we’re learning the value of masks, I’ll supplement my announcement.

Wear a condom when you have sex.

I understand the situation is different. Protecting yourself during sex is not like protecting yourself from an air-born virus. We all have to breathe every hour of every day. That’s not the same as sex. The principle is still the same, though.

It’s a simple safety measure that’s cheap, widely available, and effective when used properly. Granted, religious zealots love to make a big fuss about them both, but that’s part of a much larger problem and during a pandemic, you can’t be picky with priorities. Again, there will be a time to deal with them. This is not it.

I’ll say it again, just to belabor the point.

Wear a mask and wear condoms.

They protect you and the people around you. It’s the easiest thing anyone can do. During a global pandemic, that’s the best thing you can do to help stem the tide and save lives. That has to be our top priority now. Too many people have already died. We can prevent more deaths if we all do our part.

 

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Recounting The Dumbest Health Scare I Ever Had

Everybody makes a fool of themselves at some point in their lives. It’s inevitable. Like traffic, taxes, and boredom at a doctor’s office, it’s an ever-present prospect. You’re going to do something stupid at some point. No matter how much time passes, you’re going to look back and cringe. You’ll feel so stupid at that moment that you’ll wonder how you ever managed put your pants on that day.

Some people have more moments than others. The capable people learn and grow from them. The idiots and narcissists never learn, but make endless excuses. I don’t deny I’ve had a number of those moments in my life. Some are more foolish than others. A few are things I’m not comfortable sharing. I will, however, share one that still makes me cringe and laugh with distressing regularity.

It involves a health scare that I had a while back. Don’t worry. It’s quite possibly the dumbest health scare you’ll ever hear about that doesn’t involve a hang nail or something a kid learned in sex ed. If anyone has anything stupider, I’d love to hear it.

Before I get into detail, I need to note the context of this scare. I’m not making excuses. I’m just highlighting that it didn’t come out of nowhere. This happened shortly after a close relative began undergoing cancer treatments. On top of that, heart disease ran in my family. I had a valid reason for being overly cautious about my health.

That didn’t make what happened any less stupid.

It happened one day when I was trimming my beard. I noticed a strange bump on my lower-right chin. It didn’t feel like anything I’d felt before. I tried to look closer. I couldn’t tell what it was through my facial hair. It didn’t feel like a bruise or an ingrown hair. It just felt like a regular bump.

At first, I shrug it off. Then, I start picking at it, as people tend to do with things they don’t understand. Naturally, it starts growing. At some point, it gets a little sore. I can feel it when I chew. That’s when my mind starts racing.

What if it’s a tumor?

What if it’s some malignant cyst?

What if it’s some crazy condition I don’t even know about?

I’m not going to lie. I did start anxiously browsing WebMD for information, which you should definitely not do. Browsing WebMD in hopes of determining how sick you are is like watching old cop movies to learn how to defuse a bomb. You’re only going to make it worse.

It’s because of that I seriously considered going to my doctor. I even promised myself that, if it still hurt after a week, I would make an appointment. Thankfully, it never came to that because I soon found out what it was in the dumbest way possible.

It was a goddamn pimple.

That’s it. That’s all it was. It was just a pimple that had somehow formed in my beard and got irritated, probably because I kept picking at it. I only confirmed it was a pimple when it randomly popped. Again, I was picking at it. Having had serious acne problems since I was a teenager, I knew what pimples looked like when they popped. This just happened to be a particularly large one that my beard hid.

I wish I could say it was a relief, but I just felt so stupid at the moment that I would’ve preferred something worse. I vividly remember looking at myself in my bathroom mirror with this deadpanned expression, as though I’d just tried to cut a steak with a soup spoon. I would’ve laughed if it weren’t so pathetic.

There’s a time and a place to worry about your health. A global pandemic is bound to put everyone on edge and for wholly valid reasons. However, you don’t do yourself any favors by being stupid. If anything, you’ll only find creative ways to make it worse.

I’ve had plenty of other moments in my life when I’ve felt dumb. Given current events, I thought I’d share one about my health at a time when we’re all a little extra health conscious. No matter the situation, we’re all vulnerable to doing stupid things. We just need to be a lot more careful during a pandemic.

If anyone else has a story about moments when they felt dumb, please share them in the comments. As long as we’re all stuck at home, we might as well use it as an opportunity for extra introspection.

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Religious Zealots, Vaccines, And (Unavoidable) Hypocrisy

To some extent, a global crisis is the ultimate bullshit filter. You can bullshit your way through a lot of things. Things like politics, economics, theology, and philosophy can all be twisted and obscured by a skilled bullshitter who has little concern for the truth, ethics, or decency. However, no amount of bullshit can circumvent the grim realities of a global pandemic.

A disease like the coronavirus/COVID-19 doesn’t respond to fancy rhetoric, dogmatic beliefs, or ideological divides. It responds only to the immutable laws of physics and biology. To this virus, you’re not a liberal, conservative, Christian, Muslim, atheist, or Satanist. You’re just another host.

It’s a grim, yet sobering perspective. It’s also revealing in other ways. As I’ve noted before, I believe we’ll eventually beat this disease. Not since World War II has there been a crisis that has unified humanity’s effort to a singular cause. It will take time and people will still die, but we’ll ultimately save more lives because of the advances we make. The fact that nobody dies of Small Pox anymore is proof of that.

As hopeful as I am for this outcome, which still seems so far away, it does bring up another issue that will likely emerge once this crisis ends. That issue has less to do with the science and more to do with the religious zealots who have spent decades trying to inject themselves into scientific circles.

I’ve mentioned religion before in pointing out some of the humorous headlines they’ve inspired in this crisis, but there’s nothing funny about this particular issue. As always, I want to disclose that most religious people aren’t zealots. They don’t take their religion, their holy text, or their eccentric leaders too seriously. They believe what they believe, but live their lives as decent, loving human beings.

This is not about them.

The people I’m referring to here are the people who yell the loudest whenever someone points out a scientific fact that contradicts their preferred holy book. These are the people who demand that their theology be treated with scientific credence in a classroom. They’re also the ones who demand special treatment by the government and greater influence in society as a whole.

I single these people out because in a crisis like this, they can’t survive with the rest of society without being hypocrites in the highest order. I say that as someone who freely admits he can’t predict the future to any degree. However, I’ve met enough religious zealots in my life to surmise predictable patterns.

With that in mind, here’s how I predict religious zealots will react when a vaccine or treatment is found for COVID-19.

They’ll thank their deity and not the doctors or scientists.

They’ll eagerly get in line to receive the treatment, whatever it might be.

They’ll later claim that their deity protected them over the course of the crisis

They’ll then claim the crisis was a punishment for insert-hot-button-social-issue-here.

On top of that, they’ll do all of this with a straight face and a clear conscious. They won’t think of themselves as hypocrites, but that’s what they’ll be by the very definition of the word.

They’ll have claimed that prayer heals and protects adherents, but conveniently overlook how it failed to protect anyone during this crisis.

They’ll have claimed that any science that contradicts their theology, namely evolution, has no merit and should not be supported on any level. Then, they’ll gladly enjoy the fruits of that same science once a vaccine is perfected. Chances are they’ll go right back to bemoaning the same science because it doesn’t line up with their holy books.

Even those who openly defied orders by health officials will face few consequences for their behavior. Even if it’s proven that people suffered and died because of their reckless behavior in the face of a pandemic that doesn’t respond to prayers or preaching, they aren’t likely to change their ways. Even if their hypocrisy is thrown in their face, it won’t change them or their zealous dogma.

That’s the most frustrating part. Most reasonable people, regardless of their faith, understand that there’s a time for prayer and a time for working with the science we know to solve a big problem. Many of those working on a vaccine as I write this are religious. Some might even be motivated by their religion to save as many lives as possible. These people are truly heroic in their own right.

Those who build their religious zealotry on false promises, false hope, and even outright fraud deserve no such praise. Their theology depends on a foundation of bullshit and when a crisis like this cuts through it, then the only thing left is hypocrisy.

I take some comfort in the knowledge that, thanks to the internet and social media, a record of their hypocrisy will remain. They might try to bullshit their way around the facts, but at some point, all the bullshit in the world can’t overcome such hypocrisy.

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Six Technologies The Coronavirus/COVID-19 Pandemic Could Accelerate

Humanity is capable of amazing feats when given the right incentive and circumstances. The problem is that humanity is also rather stubborn when it comes to incentives and exceedingly evasive when it comes to changing circumstances. We’ll go the extra distance and beat the odds eventually. We just need to be dragged kicking and screaming for a while.

When it comes to the ultimate incentives and circumstances, few check more boxes than a global pandemic. I don’t think I need to belabor how bad the ongoing Coronavirus/COVID-19 pandemic has been. Even without media distortions and political agendas, there’s no getting around the damage it has and continues to inflict.

People are dying.

People suffering.

Societies and economies are teetering on the brink of collapse.

This is not a tenable situation and one nobody wants to see again. As bad as it is, there might be one silver lining to this global tragedy. It could help accelerate the development of technology that was already in the works, but lacked the necessary motivation to develop faster.

What follows are a few technologies that I believe this horrible pandemic might help in the sense that it’ll add some urgency. Nobody wants to see a mess like this again. Whether you’re rich, poor, powerful, or powerless, we have every reason to find new ways of preventing these plagues before they happen and these technologies are instrumental in doing just that.


Artificial Intelligence (Not Necessarily The Advanced Kind)

It’s impossible to overstate the potential benefits of artificial intelligence. I’ve certainly made a concerted effort when writing about it in the past. However, in the context of battling plagues, we don’t necessarily need the kind of super-advanced, super-intelligent AI to provide some of those benefits. When it comes to combating plagues, we don’t need an AI to be as intelligent as a human. We just need it to help us combat deadly disease.

This can be done without the kind of AI that finds its way into Skynet or Hal 9000. An AI that can better-analyze genetic data, run simulations on possible treatments, and track the spread of a disease can do plenty to prevent or mitigate future plagues. If it can just help us identify and isolate new cases in a short span of time, then that alone could save millions.

At a certain point, AI could get powerful enough to calculate entire treatment programs once it has the genetic data of a pathogen or condition. After this global, well-publicized crisis, it’ll have plenty of data to work with.


Space-Based Broadband Internet

When it comes to dealing with pandemics, the incentives don’t stop at treating the disease. Given all the closures and cancellations caused by COVID-19, we now know how challenging it is to endure an extended quarantine, especially for kids with no school and sports fans with no sports.

Enduring this crisis has revealed just how critical it is to have a strong, robust internet connection. It may not treat the disease, but it makes the measures recommended by the authorities more bearable. The problem is our current infrastructure for the internet is badly in need of upgrades and its role in helping us function has been made abundantly clear during this crisis.

For work, play, and just avoiding crippling boredom, we need a better internet. That’s where space-based internet, like the ones being developed by companies like FaceBook and Google come in. The idea is as simple as it is awesome. Use satellites and other high-flying crafts to deliver data more efficiently and reliably.

There are a few space-based internet service providers now, but they’re incredibly limited. This crisis, which needs reliable internet for so many reasons, might help pick up the pace in refining this technology. At the very least, it will allow people to binge-watch Netflix from the summit of Mount Everest.


Nanoparticle Vaccines

On the medical side of things, this crisis should go a long way towards teaching people the importance of vaccines. While I don’t doubt the anti-vax crowd will find an excuse to protest, even those skeptical of modern medicine can’t deny the need for better preventative measures for these treatments. Unfortunately, vaccine technology has been stagnant for decades.

This pandemic will hopefully change that and not a minute too soon. The current process for producing a vaccine is long and cumbersome, taking upwards of two years. It’s a process that has a lot of room for improvement. That’s where technology like nanoparticles come in.

The key to any medical treatment is the effectiveness of the delivery system. Vaccines have always had to take a messy path, but nanoparticles could change that. Instead of relying on the biological equivalent of a blunt instrument, nanoparticles could become biological smart-bombs, targeting pathogens with the precision we need to keep them from ever becoming pandemics.

Anti-vaxxers who refuse these just have a death with.


Gene Editing/Synthetic Biology

Not unlike vaccines, gene editing and synthetic biology stand to get a major boost from this crisis. I’ve written about gene editing tool like CRISPR in the past. I’ve touted it as a tool that could potentially treat all infectious disease, especially when combined with synthetic biology. That might have been hyperbole, but I stand by my claims on it’s potential.

Gene editing can do more than make pet fish glow. In theory, it can tweak and rewrite the DNA of organism, including the viruses that infect us. The challenge is refining the procedure so that we know how to modify diseases or create entirely new organisms that combat them through synthetic biology.

It’s not a small challenge. I’m grossly oversimplifying the obstacles in refining this technology into something usable. However, those obstacles are not insurmountable. It just requires time, resources, and motivation. After being economically and socially ravaged by a global pandemic, these efforts will have a lot more urgency.


Immersive Virtual Reality

While the scientists and doctors take up the challenge of fighting future pandemics, the rest of us are tasked with enduring the boredom they incur. I’ve noted before how boredom could become the plague of the future. I hope those stuck at home for weeks on end are done doubting me.

The entertainment industry may never be as vital as the medical industry, but it’ll play an important role in helping people stay sane, calm, and kind. Binge-watching TV and playing video games is helpful, but there’s room for improvement. At the end of the day, you’re still just sitting on a couch, looking at a screen.

To keep things both interesting and active, the development of virtual reality should get a major boost. It has existed for years and grown considerably from the days of the Virtual Boy, but it has room for improvement. Thanks to improving computer technology and more advanced interfaces like Neuralink, the experience could become even more immersive.

Beyond simply treating boredom, it could allow a greater sense of active engagement, which is critical when everyone is practicing social distancing. Being isolated and cut off from human contact may help temper a plague, but it’s not healthy. A way to immerse yourself in a realistic environment could help make future quarantines more bearable while also opening a new market, which gaming companies are sure to exploit.


Sex Robots (Obviously)

Does this one really need an explanation? When you’re stuck inside, horny, and run out of things to binge-watch, things are going to happen. Even if your partner or significant other is with you, they might get sick and you might feel lonely. Given how pandemics tend to temper the market for sex workers, a sex robot might be the best and only option.

If at least one company or horny entrepreneur hasn’t realized that by now, I’ll be shocked. The market for sex robots has been growing in recent years. After enduring a pandemic and weeks of social isolation, that market has likely grown. People rarely forget big global events like this. They’ll remember how lonely they were and that memory will fuel the development of sex robots more than any libido.

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Body Weight Exercises For Those Wanting To Stay In Shape During A Crisis

At this point, almost everyone’s life has been disrupted in some form or another by the ongoing Coronavirus/COVID-19 pandemic. Unless you live on a deserted island, a cave, or shack in the mountains, you’ve been effected by this crisis. Whether it’s living in an area that’s on total lockdown or just had your favorite sporting events cancelled, you’re feel the pinch of this crisis.

I certainly have. Recently, the crisis hit home in another profound way. Every gym in my area, including the one I go to on a regular basis, closed for the foreseeable future. A few may not open again until mid-May. That’s a long time to not have access to a gym. If ever you wanted an excuse to avoid working out, this is it.

However, I actually enjoy working out. That’s something my 21-year-old self might laugh at, but it’s true. Working out is one of the most cathartic parts of my week. The prospect of not having a gym to go to is genuinely jarring for me.

As difficult as it is, that doesn’t mean I’m just going to let myself go. I still intend to stay in shape and I strongly encourage everyone else to do the same. If you have free weights, an exercise bike, a treadmill, or some other piece of gym equipment in your house, I say use it. I don’t because I always had access to a gym. I didn’t imagine everything could be shut down to this extent.

Luckily, there are ways to stay in shape without the aid of equipment. I know because I’ve used them whenever I’ve had to travel or be away from home for an extended period. They mostly consist of bodyweight exercises, which is exactly what it sounds like. You work out, but you don’t use weights or a machine. You just use your body, physics, and a clear space.

They’re not quite as effective or satisfying, in my opinion, as using weights. They still get the job done for the most part. Combined with regular running and jogging, which I highly recommend as well, you can maintain your health and your physique. At a time when a novel disease is ravaging civilization, good health has never been more important.

To that effect, here are some handy charts I’ve found that depict both the types of bodyweight exercises you can do and ways to go about doing them. If I find a routine that works, I’ll gladly share it. If you have a routine, please share it in the comments.

Image result for bodyweight exercise

Image result for bodyweight workout

See the source image

Stay safe, stay healthy, and stay awesome everyone.

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A (Hopeful) Perspective On The Coronavirus

See the source image

As a general rule, I always watch the news with a skeptical eye. That’s not just because we live in an era of fake news, misguided outrage, and conspiracy theories about shape-shifting lizard people. I’ve learned from time, experience, and observation that the news can only ever tell part of a story as it’s happening. The full story never comes out until much later. Sometimes, it’s years later.

That’s not easy when following stories like the coronavirus. Unlike other major news stories that make headlines for all the wrong reasons, this is a serious issue. This is something the public needs to know about. The coronavirus is not just a nasty cold. It’s killing people all over the world. That’s an indisputable fact and one that warrants serious concern.

At the same time, there’s a context worth noting. As bad as the coronavirus is, it’s not the second coming of the Black Death or the Spanish Flu. This is not the kind of disease that will turn the planet into a post-apocalyptic wasteland in the mold of a Stephen King novel. It’s still serious, but it’s not a global cataclysm. Even if it ends up killing millions, there are over 7.6 billion people on this planet.

Human beings adapt.

Human beings survive.

It’s one of the few things we’re good at.

There’s another perspective worth considering when following the news of the coronavirus. Unlike the devastating plagues of the past, humanity has developed a decent infrastructure for medicine, technology, and research. Granted, it took us centuries of trial, error, and mass death and there’s still plenty of room for improvement, but that system is there. It’s better than nothing. Just ask Medieval Europe.

That system is already doing its job in combating the virus. Already, researchers at the University of Texas in Austin have mapped out critical portions of the virus. That sort of thing couldn’t have been done this quickly or at all just 30 years ago. This data is critical for the development of treatments and, ultimately, a vaccine.

The fact that this happened so quickly after the outbreak is something the news hasn’t reported on. Even if treatments develop and the virus is contained, as we’ve seen with other recent outbreaks, it probably won’t be a huge story within the ever-changing news cycle.

We know this because in late 2019, the first vaccine for Ebola was approved for use by the FDA and it barely showed up in the headlines. Considering how much panic the Ebola outbreak caused several years ago, this is quite a triumph. It shows just how quickly our current system can respond to these diseases.

Again, there’s still room for improvement and accessibility to medicine is a major issue, but the coronavirus is not some new form of disease. It’s a virus. We know what viruses are. We have the technology to study, treat, and combat them, more so than we have at any point in human history. Considering how much better we’ve gotten since the heyday of the AIDS pandemic, I say that’s reason to be hopeful.

That doesn’t mean we should let our guard down. When the CDC issues a warning about the coronavirus, we should take it seriously. At the same time, we should take comfort in the knowledge that we live in an era where human ingenuity has limited the suffering caused by these devastating plagues.

As with Ebola, we will eventually develop a treatment for the coronavirus. It won’t be perfect, but it will limit the death and suffering it causes. It also won’t make the news because it’s just not scary or dire enough. At this point, finding effective treatments for diseases is so mundane it barely qualifies as news. That’s an objectively good thing.

I hope that helps provide a bit of context and hope to the news surrounding the coronavirus. It’s still worth taking seriously, but we shouldn’t let grim headlines distract us from the great things that humanity achieves when faced with a challenge.

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How Humanity Will Cure Death

immortality

When it comes to pushing the limits of technology, every goal once started as a fantasy. In the 19th century, the smartest minds of the time thought heavier-than-air flying machines were infeasible at best and impossible at worst. In the early 20th century, other people with legitimate scientific credentials said the same thing about a manned mission to the moon.

While it seems absurd today, at the time it made sense. The people of that era just couldn’t imagine technology advancing to a point where humanity regularly achieved feats that had once been relegated to science fiction. It’s easy it mock them with the benefit of hindsight, but there are plenty of smart people today who have made claims that will be mocked 50 years from now.

One claim that most individuals, including those who work at the forefront of science and research, is that we will never cure death. Science is certainly capable of doing a great deal, but death is one of those immutable barriers that it can never overcome.

We may be able to cure all infectious disease through biotechnology and genetic engineering. We may one day have technology that allows our bodies to become so durable that from the perspective of people alive today, they’ll be superhuman. They may even live for centuries, but never age past 30. Nothing other than a freak accident could kill them. I’ve already noted the potential issues with that.

However, even these highly-enhanced humans will eventually die at some point. That seems like a given. Efforts to avoid it are often subject to heavy criticism, especially approaches like cryonics or uploading your mind into a computer. While some of those criticisms are valid, they’re also short-sighted. They work under the same assumption as those who claimed humans would never walk on the moon.

Technology has limits, but humans have a bad track record with respect to understanding those limits. With respect to curing death, even the most advanced fields of emerging technology seem limited in their ability to help people escape such a fate. That doesn’t mean the concept is flawed. It doesn’t even mean that the technology is beyond the laws of physics.

Personally, I believe death can be cured, but not with approaches like cryonics or bodily enhancements. While those technologies may ultimately extend our lives, being able to transcend death requires another approach. Specifically, it requires a mechanism for preserving, transforming, and transferring the contents of our brains.

Medically speaking, the official definition of death is the irreparable cessation of all brain activity. Your body can be damaged. Every other organ could fail. Your brain is the last link in that chain. It contains your memories, your emotions, your personality, and your capacity to experience the world. To cure death, we simply need to preserve the brain and all its functions.

That’s much harder than it sounds, but it’s not physically impossible. The human brain is not made up of some mythical, exotic material. It’s made up of specialized cells and tissues, like any other organ. While we don’t entirely understand the workings of the brain, it operates using physical matter that is bound by the laws of physics and biology.

Those limits are the key and the mechanism for preserving that complex clump of biomatter already exists, both as a concept and in a very unrefined form. That technology involves nanobots and if there’s one technology that has the potential to make humans truly immortal, it’s this.

The concept of nanobots is already a common staple of science fiction, but it’s primarily used as the technological equivalent of a wizard’s spell. If you need something or someone to do the impossible without resorting to magic, just throw nanobots or nanites, as they’re often called, into the story and let the impossible seem mundane.

While it’s doubtful that nanobots can do everything that science fiction claims, there’s a good chance that they’ll come pretty close. It’s impossible to overstate the potential of nanorobotics. From mass-producing any kind of good to curing humans of all infectious disease, nanobots have the potential to literally and figuratively change our lives, our bodies, and our world.

At the moment, we only have crude prototypes. In time, though, nanobots could become something akin to programmable matter and, by default, programmable flesh. Technically speaking, a nanobot could be programmed to do whatever a typical brain cell does, but more efficiently.

In the late 90s, scientists like Robert Freitas Jr. envisioned nanobots called respirocytes, which functioned like artificial blood cells. In theory, these would be far more effective at getting air and nutrients to the rest of your body, so much so that you could hold your breath for hours or sprint indefinitely.

That’s all well and good for deep sea diving and Olympic sprinters, but for curing death, the concept needs to go even further. That means creating nanobots that mimic the same function as a neuron, but with more efficiency and durability. Create enough of those and you’ve got the exact same hardware and functionality as the brain, but with the utility of a machine.

Once we have that technology refined and perfected, we have everything we need to effectively cure death. Doing so means gradually replacing every neuron in our skulls with a more efficient, more durable nanobot that does everything that neuron did, and then some. The most important additional feature these nanobots would have is a measure of intelligence that could be programmed.

By being programmable, the nanobots in our skulls would be more plastic. It would be less an organ and more a synthetic substrate, of sorts. It could be drained into a container, implanted into a robot specifically designed to contain it, or just preserved indefinitely in the event that there are no bodies available, not unlike the systems used in, “Altered Carbon.”

To some, this still doesn’t count because it requires that every cell in our brains be replaced with something. Technically, that brain wouldn’t be yours and you might not even be use, as a result. I respectfully disagree with this criticism, primarily because it ignores the whole Ship of Theseus argument.

If you’re not familiar with this concept, it’s pretty simple, but the implications are profound. It starts with a real, actual ship used by the mythical hero, Theseus. If, at one point, you replace a piece of wood in that ship, it’s still the same ship. However, the more pieces you replace, the less of the original ship you have. Eventually, if you replace all pieces, is it the same ship?

The human brain, or any organ in your body, is an extreme version of that thought experiment. The brain cells can replicate, but it’s a slower process compared to most cells and the configurations are always changing. The way your brain is wired now is changing as you read this sentence. A cluster of nanobots doing the same thing won’t be any different.

Like the Ship of Theseus, it wouldn’t happen all at once. In principle, the brain cell doesn’t even get destroyed. It just gets subsumed by the mechanizations of the nanobot. How it goes about this is hard to determine, but there’s nothing in the laws of physics that prohibit it. At the molecular level, it’s just one set of atoms replacing another.

Once in place, though, the limits of biology go out the window. With programmable nanobots, a person doesn’t just have the same functionality as a biological brain. It’s has other functions that allow for easier programming. We could, in theory, supplement the nanobots with additional material, sort of like cloud computing. It could even create a neurobiological backup of your brain that could be kept in stasis.

At that point, death is effectively cured. Once your brain becomes a substrate of nanobots, you can just transfer it into a body, a robot, or some other containment vessel that allows it to experience the world in any way desired. If, by chance, that body and the substrate are destroyed or damaged, then the backup kicks in and it’ll be like you just jumped from one place to another.

Some of this relies on an improved understanding of how consciousness works and assumes that it could be somehow transferred, expanded, or transmitted in some way. That may very well be flawed. It may turn out to be the case that, even if you turn your brain into a glob of nanobots, you can’t transmit your consciousness beyond it. If it gets destroyed, you die.

There’s a lot we currently don’t understand about the mechanisms of consciousness, let alone our ability to manipulate those mechanisms. However, a lack of understanding doesn’t negate the possibilities. Our previous inability to understand disease didn’t prevent our ancestors’ ability to treat it to some extent.

If it is the case that we cannot transmit consciousness from our brains, then we can still craft a functional cure for death. It just requires that we put our brains in protective vats from which carry out our existence in a simulated world. Those vats could be protected in a massive artificial planet that’s powered by a black hole or neutron star. In theory, our brains would be preserved until the heat death of the universe.

Whatever the limitations, the technology and the concepts are already in place, if only on paper. It’s difficult to know whether anyone alive today will live long enough to see an advancement like this. Then again, the children alive in 1900 probably didn’t think they would live to see a man walk on the moon.

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The First Genetically Modified Humans Have Been Born: Now What?

designerbabies

When the USSR launched Sputnik 1 on October 4, 1957, it didn’t just kick-start the space race. It marked a major technological paradigm shift. From that moment forward, venturing into space wasn’t just some futuristic fantasy. It was real and it had major implications for the future of our species.

On November 26, 2018, a Chinese scientist named He Jiankui announced that the first genetically modified humans had been born. Specifically, two twin girls actually had their genetic code modified at the embryonic stage to disable the CCR5 gene to make them highly resistant to HIV/AIDS. In the history of our species, this moment will likely exceed the importance of Sputnik.

This man may have just upstaged Neil Armstrong.

To appreciate why this is such a big deal, consider the full ramifications of what Mr. Jiankui achieved. The change he made to the genome of those girls was impossible for them to inherent. This particular allele is a result of a mutation within a small population of Northern Europeans and is present in no other ethnic group. It is best known for providing significant immunity to common strains of the HIV virus.

This is of significant interest to China because they’ve been dealing with a surge in HIV/AIDS rates in recent years. Even though AIDS isn’t a death sentence anymore, the medicine needed to manage it is costly and tedious. These two girls, who have not been publicly named thus far, may now have a level of resistance that they never would’ve had without genetic modification.

On paper, that’s an objective good. According to the World Health Organization, approximately 35 million people have died because of AIDS since it was first discovered and approximately 36.9 million people are living with the disease today. It’s in the best interest of society to take steps towards preventing the spread of such a terrible disease, especially in a country as large as China.

However, Mr. Jiankui has caused more consternation than celebration. Shortly after he announced the birth of the two unnamed children, China suspended his research activities. Their reasoning is he crossed ethical boundaries by subjecting humans to an untested and potentially dangerous treatment that could have unforeseen consequences down the line.

Those concerns have been echoed by many others in the scientific community. Even the co-inventor of CRISPR, the technology used to implement this treatment and one I’ve cited before as a game-changer for biotechnology, condemned Mr. Jiankui’s work. It’s one thing to treat adults with this emerging technology. Treating children in the womb carries a whole host of risks.

That’s why there are multiple laws in multiple countries regulating the use of this technology on top of a mountain of ethical concerns. This isn’t about inventing new ways to make your smartphone faster. This involves tweaking the fundamental code of life. The potential for good is immense, but so is the potential for harm.

Whether or not Mr. Jiankui violated the law depends heavily on what lawyers and politicians decide. Even as the man defends his work, though, there’s one important takeaway that closely parallels the launch of Sputnik. The genie is out of the bottle. There’s no going back. This technology doesn’t just exist on paper and in the mind of science fiction writers anymore. It’s here and it’s not going away.

Like the space race before it, the push to realize the potential of genetic modification is officially on. Even as the scientific and legal world reacts strongly to Mr. Jiankui’s work, business interests are already investing in the future of this technology. The fact this investment has produced tangible results is only going to attract more.

It’s impossible to overstate the incentives at work here. Biotechnology is already a $139 billion industry. There is definitely a market for a prenatal treatment that makes children immune to deadly diseases. Both loving parents and greedy insurance companies have many reasons to see this process refined to a point where it’s as easy as getting a flu shot.

Even politicians, who have historically had a poor understanding of science, have a great many reasons to see this technology improve. A society full of healthy, disease-free citizens is more likely to be prosperous and productive. From working class people to the richest one percent, there are just too many benefits to having a healthy genome.

The current climate of apprehension surrounding Mr. Jiankui’s work may obscure that potential, but it shouldn’t surprise anyone. During the cold war, there was a similar climate of fear, albeit for different reasons. People back then were more afraid that the space race would lead to nuclear war and, given how close we came a few times, they weren’t completely unfounded.

There are reasons to fear the dangers and misuse of this technology. For all we know, the treatment to those two girls could have serious side-effects that don’t come to light until years later. However, it’s just as easy to argue that contracting HIV and having to treat it comes with side-effect that are every bit as serious.

As for what will come after Mr. Jiankui’s research remains unclear. I imagine there will be controversy, lawsuits, and plenty of inquiries full of people eager to give their opinion. As a result, he may not have much of a career when all is said and done. He won’t go down in history as the Neil Armstong of biotechnology, but he will still have taken a small step that preceded a giant leap.

Even if Mr. Jiankui’s name fades from the headlines, the breakthrough he made will continue to have an impact. It will likely generate a new range of controversy on the future of biotechnology and how to best manage it in an ethical, beneficial manner. It may even get nasty at times with protests on par or greater than the opposition to genetically modified foods.

Regardless of how passionate those protests are, the ball is already rolling on this technology. There’s money to be made for big business. There’s power and prosperity to be gained by government. If you think other countries will be too scared to do what a science team in China did, then you don’t know much about geopolitics.

Before November 26, 2018, there were probably many other research teams like Mr. Jiankui who were ready and eager to do something similar. The only thing that stopped them was reservation about being the first to announce that they’d done something controversial with a technology that has been prone to plenty of hype.

Now, that barrier is gone. Today, we live in a world where someone actually used this powerful tool to change the genome of two living individuals. It may not seem different now, but technology tends to sneak up on people while still advancing rapidly. That huge network of satellites that now orbit our planet didn’t go up weeks after Sputnik 1, but they are up there now because someone took that first step.

There are still so many unknowns surrounding biotechnology and the future of medicine, but the possibilities just become more real. Most people alive today probably won’t appreciate just how important November 26, 2018 is in the history of humanity, but future generations probably will, including two remarkable children in China.

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Filed under futurism, gender issues, sex in society, Sexy Future, technology