Category Archives: CRISPR

Why We Should Embrace Synthetic Meat (As Soon As Possible)

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If you’re reading this, then there’s a good chance you drank milk at some point this year. You probably drank a lot more of it when you were a kid. The fact that you’re reading this proves that you didn’t die, as a result. That may not seem like a big deal, but compared to 100 years ago, it counts as a noteworthy feat.

Between 1850 and 1950, approximately a half-million infants died due to diseases contracted by drinking milk. If you do the math, that’s about 5,000 deaths a year, just from drinking milk. Keep in mind, these are children. That’s a lot of death and suffering for drinking one of the most basic substances the animal kingdom.

These days, death by drinking milk is exceedingly rare. Thanks to processes like pasteurization, milk is one of the safest substances you can drink. If anyone does get sick, it’s usually from drinking raw or unpasteurized milk. However, it’s so rare that most people don’t think about it. It’s just a normal part of how we manage our food and nourish ourselves.

I bring up milk because it nicely demonstrates what happens when we apply technology to improve the quality, safety, and abundance of our food. Despite what certain misguided critics may say, many of which probably haven’t experienced extreme starvation, this has been an objective good for humanity, civilization, and the world, as a whole.

Modern medicine and the Green Revolution, championed by the likes of Norman Borlaug, helped give us more efficient ways of producing massive quantities of food. Now, there’s another technological advancement brewing that might end up being more impactful. You’ve probably seen commercials for it already. It has many names, but for now, I’m just going to call it synthetic meat.

It’s almost exactly what it sounds like. It’s the process of producing meat through artificial processes, none of which involve the slaughtering of animals. For those concerned about animal welfare and environmental impacts, it’s the ultimate solution. At most, the animals contribute a few cells. The rest is grown in a laboratory. Nobody has to get hurt. Nobody has to go vegan, either.

It seems too good to be true and there are certainly aspects of synthetic meats that are overhyped. However, unlike other advancements like Neuralink or nanobots, this is already an evolving market. The first synthetic burger was made and consumed in 2013. It was the culmination of a long, laborious effort that cost upwards of $300,000.

Those costs soon came down and they came down considerably. By 2017, the cost of that same meat patty was around $11. People have paid much more for expensive caviar. That’s impressive progress for something that’s still a maturing technology with many unresolved challenges. With major fast food companies getting in on the game, the technology is likely to progress even more.

It’s here where I want to make an important point about this technology. Regardless of how you feel about it or why it’s being developed, there’s one aspect to it that’s worth belaboring.

We should embrace synthetic meat.

In fact, we should embrace this technology faster than others because the benefits of doing so will only compound.

I say this as someone who has tried an impossible meat burger. It’s not terrible. I wouldn’t mind eating them regularly if they were the only option available. That said, you can still tell it’s not traditional beef. That’s because this meat isn’t exactly the kind of cultured meat that’s grown in a lab. It’s assembled from plant proteins and various other well-known substances.

Ideally, synthetic meat wouldn’t just be indistinguishable from traditional beef. It would actually be safer than anything you could get naturally. Meat grown in a lab under controlled conditions can ensure it’s free of food-born illnesses, which are still a problem with meat production. It can also more effectively remove harmful byproducts, like trans fats.

In theory, it might also be possible to produce meat with more nutrients. Imagine a burger that’s as healthy as a bowl of kale. Picture a T-bone steak that has the same amount of nutrients as a plate of fresh vegetables. That’s not possible to do through natural means, but in a lab where the meat is cultured at the cellular level, it’s simply a matter of chemistry and palatability.

Meat like that wouldn’t just be good for our collective health. It would be good for both the environment and the economy, two issues that are rarely aligned. Even if you don’t care at all about animal welfare, synthetic meats has the potential to produce more product with less resources. On a planet of over 7.6 billion, that’s not just beneficial. It’s critical.

At the moment, approximately 70 percent of the agricultural land in the world is dedicated to the meat production. In terms of raw energy requirements, meat requires considerably more energy than plants. That includes water consumption, as well. Making meat in its current form requires a lot of resources and with a growing population, the math is working against us.

Say what you want about vegetarians and vegans when they rant about the meat industry. From a math and resources standpoint, they have a point. However, getting rid of meat altogether just isn’t feasible. It tastes too good and it has too many benefits. We can’t make people hate the taste of burgers, but we can improve the processes on how those burgers are made.

Instead of industrial farms where animals are raised in cramped quarters, pumped full of hormones, and raised to be slaughtered, we could have factories that produce only the best quality meat from the best animal cells. It wouldn’t require vast fields or huge quantities of feed. It would just need electricity, cells, and the assorted cellular nutrients.

Perhaps 3D printing advances to a point where specific cuts of meat could be produced the same way we produce specific parts for a car. Aside from producing meat without having to care for than slaughter animals, such a system would be able to increase the overall supply with a smaller overall footprint.

Needing less land to produce meat means more land for environmental preservation or economic development. Farming, both for crops and for meat, is a major contributor to deforestation. Being able to do more with less helps improve how we utilize resources, in general. Even greedy corporations, of which the food industry has plenty, will improve their margins by utilizing this technology.

Increased supply also means cheaper prices and if the taste is indistinguishable from traditional meat, then most people are going to go with it, regardless of how they feel about it. There will still be a market for traditional, farm-raised meats from animals, just as there’s a market for non-GMO foods. However, as we saw with the Green Revolution in the early 20th century, economics tends to win out in the long run.

It’s a promising future for many reasons. There are many more I could list relating to helping the environment, combating starvation, and improving nutrition. Alone, they’re all valid reasons to embrace this technology and seek greater improvements. If I had to pick only one, though, it’s this.

If we don’t develop this technology, then these delicious meats that we love could be exceedingly scarce or prohibitively expensive in the future.

Like I said earlier, the way we currently produce meat is grossly inefficient. At some point, the demand for meat is going to exceed the current system’s capacity to produce it in an economical way. At that point, this delicious food that we take for granted might not be so readily available and the substitutes might not be nearly as appetizing.

The issue becomes even more pressing if we wish to become a space-faring civilization, which will be necessary at some point. If we still want to enjoy burgers, chicken wings, and bacon at that point, we’ll need to know how to make it without the vast fields and facilities we currently use. Otherwise, we might be stuck dining on potatoes like Matt Damon in “The Martian.”

While the situation isn’t currently that urgent, this is one instance where a new technology is the extra push. You don’t have to be a major investor in companies like Beyond Meat or Impossible Foods. Just go out of your way to try one of these new synthetic meat products. Let the market know that there’s demand for it and the machinations of capitalism will do the rest.

I understand that our inner Ron Swanson will always have a craving for old fashioned burgers, steaks, and bacon. Those things don’t have to go away completely, just as traditional farming hasn’t gone away completely. However, when a particular technology already exists and has so many potential benefits, it’s worth pursuing with extra vigor.

The planet will benefit.

The people will benefit.

The animals will benefit.

Our society, as a whole, will benefit.

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Filed under biotechnology, CRISPR, Current Events, Environment, futurism, health, technology

The First CRISPR Patients Are Living Better: Why That Matters After 2020

It’s been a while since I’ve talked about CRISPR, biotechnology, and the prospect of ordinary people enhancing their biology in ways straight out of a comic book. In my defense, this past year has created plenty of distractions. Some have been so bad that my usual optimism of the future has been seriously damaged.

While my spirit is wounded, I still have hope that science and technology will continue to progress. If anything, it’ll progress with more urgency after this year. A great many fields are bound to get more attention and investment after the damage done by a global pandemic.

We can’t agree on much, but we can at least agree on this. Pandemics are bad for business, bad for people, bad for politics, and just objectively awful for everyone all around, no matter what their station is in life.

There’s a lot of incentive to ensure something like this never happens again is what I’m saying. While we’re still a long way from ending pandemics entirely, we already have tools that can help in that effort. One is CRISPR, a promising tool I’ve talked about in the past. While it wasn’t in a position to help us during this pandemic, research into refining it hasn’t stopped.

Despite all the awful health news of this past year, some new research has brought us some promising results on the CRISPR front. In terms of actually treading real people who have real conditions, those results are in and they give us reason to hope.

One such effort involved using CRISPR to help treat people with Sickle Cell Disease, a genetic condition that hinders the ability of red blood cells to carry oxygen. It affects over 4 million people worldwide and often leads to significant complications that can be fatal.

Since CRISPR is all about tweaking genetics, it’s a perfect mechanism with which to develop new therapies. Multiple patients have undergone experimental treatments that utilize this technology. In a report form NPR, the results are exceeding expectations for all the right reasons.

NPR: First Patients To Get CRISPR Gene-Editing Treatment Continue To Thrive

At a recent meeting of the American Society for Hematology, researchers reported the latest results from the first 10 patients treated via the technique in a research study, including Gray, two other sickle cell patients and seven patients with a related blood disorder, beta thalassemia. The patients now have been followed for between three and 18 months.

All the patients appear to have responded well. The only side effects have been from the intense chemotherapy they’ve had to undergo before getting the billions of edited cells infused into their bodies.

The New England Journal of Medicine published online this month the first peer-reviewed research paper from the study, focusing on Gray and the first beta thalassemia patient who was treated.

“I’m very excited to see these results,” says Jennifer Doudna of the University of California, Berkeley, who shared the Nobel Prize this year for her role in the development of CRISPR. “Patients appear to be cured of their disease, which is simply remarkable.”

Make no mistake. This is objectively good news and not just for people suffering from sickle cell disease.

Whenever new medical advances emerge, there’s often a wide gap between developing new treatments and actually implementing them in a way that makes them as commonplace as getting a prescription. The human body is complex. Every individual’s health is different. Taking a treatment from the lab to a patient is among the biggest challenge in medical research.

This news makes it official. CRISPR has made that leap. The possible treatments aren’t just possibilities anymore. There are real people walking this planet who have received this treatment and are benefiting because of it. Victoria Gray, as referenced in the article, is just one of them.

That’s another critical threshold in the development of new technology. When it goes beyond just managing a condition to helping people thrive, then it becomes more than just a breakthrough. It becomes an opportunity.

It sends a message to doctors, researchers, and biotech companies that this technology works. Some of those amazing possibilities that people like to envision aren’t just dreams anymore. They’re manifesting before our eyes. This is just one part of it. If it works for people with Sickle Cell Disease, what other conditions could it treat?

I doubt I’m the first to ask that question. As I write this, there are people far smarter and more qualified than me using CRISPR to develop a whole host of new treatments. After a year like 2020, everyone is more aware of their health. They’re also more aware of why science and medicine matter. It can do more than just save our lives. It can help us thrive.

We learned many hard lessons in 2020, especially when it comes to our health. Let’s not forget those lessons as we look to the future. This technology is just one of many that could help us prosper in ways not possible in previous years. We cheered those who developed the COVID-19 vaccine. Let’s start cheering those working on new treatments with CRISPR.

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Why Biological Weapons Will Be A (MUCH) Bigger Threat In The Future

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It wasn’t too long ago that the biggest existential threat facing humanity was nuclear war. I’ve noted before how distressingly close we’ve come to a nuclear disaster and how the threat of a nuclear holocaust is still present. However, that threat has abated in recent decades, especially as nuclear weapons have gotten so destructive that their use is somewhat redundant.

More recently, people have become more concerned about the threat posed by advanced artificial intelligence. The idea is that at some point, an AI will become so intelligent and capable that we won’t be able to stop it in the event it decides that humanity must go extinct. It’s the basis of every Terminator movie, as well as an Avengers movie.

While I certainly have my concerns about the dangers of advanced artificial intelligence, it’s not the threat that worries me most these days. We still have some measure of control over the development of AI and we’re in a good position to guide that technology down a path that won’t destroy the human race. The same cannot be said for biological weapons.

If there’s one true threat that worries me more with each passing day, it’s that. Biological weapons are one of those major threats that does not slip under the radar, as evidenced by plenty of movies, books, and TV shows. However, the extent of that threat has become more understated in recent years and has the potential to be something more powerful than nuclear weapons.

By powerful, I don’t necessarily mean deadlier. At the end of the day, nuclear weapons are still more capable of rendering the human race extinct and turning the whole planet into a radioactive wasteland. The true power of biological weapons less about how deadly they can be and more about how useful they could be to potential governments, tyrants, or extremists.

For most of human history, that power has been limited. There’s no question that disease has shaped the course of human history. Some plagues are so influential that they mark major turning points for entire continents. The same can be said for our ability to treat such diseases. However, all these diseases had one fatal flaw that kept them from wiping out the human race.

Thanks to the fundamental forces of evolution, a deadly pathogen can only be so deadly and still survive. After all, an organism’s ultimate goal isn’t to kill everything it encounters. It’s to survive and reproduce. It can’t do that if it kills a carrier too quickly. If it’s too benign, however, then the carrier’s immune system will wipe it out.

That’s why even diseases as deadly as Ebola and Influenza can only be so infectious. If they kill all their hosts, then they die with them. That’s why, much to the chagrin of creationists, evolution doesn’t favor the natural emergence of apocalyptic diseases. They can still devastate the human race, but they can’t necessarily wipe it out. It would only wipe itself out in the process and most lifeforms avoid that.

It’s also why the large-scale biological weapons programs of the 20th century could only be so effective. Even if a country manufactured enough doses of an existing disease to infect every person on the planet, it won’t necessarily be deadly enough to kill everyone. Even at its worst, smallpox and bubonic plague never killed more than two-thirds of those it infected.

That’s not even factoring in how difficult it is to distribute these pathogens to everyone without anyone noticing. It’s even harder today because powerful governments invest significant resources into preventing and containing an outbreak. If large numbers of people start getting sick and dropping dead at a rapid rate, then someone will notice and take action.

That’s why, for the most part, biological weapons are both ethically untenable and not very useful as weapons of mass destruction. They’re difficult to control, difficult to distribute, and have unpredictable effects. They also require immense resources, considerable technical know-how, and a keen understanding of science. Thankfully, these are all things that extreme religious zealots tend to lack.

For the most part, these powerful constraints have kept biological weapons from being too great a threat. However, recent advances in biotechnology could change that and it’s here where I really start to worry. With recent advances in gene-editing and the emergence of tools like CRISPR, those limitations that kept biological weapons in check may no longer be insurmountable.

While I’ve done plenty to highlight all the good that tools like CRISPR could do, I don’t deny that there are potential dangers. Like nuclear weapons, this technology is undeniably powerful and powerful technology always carries great risks. With CRISPR, the risks aren’t as overt as obvious as fiery mushroom clouds, but they can be every bit as deadly.

In theory, CRISPR makes it possible to cut and paste genetic material with the same ease as arranging scattered puzzle pieces. With right materials and tools, this technology could be used to create genetic combinations in organisms that could never occur naturally or even with artificial selection.

Imagine a strain of smallpox that was lethal 100 percent of the time and just as infectious.

Imagine a strain of the flu that was as easy to spread as the common cold, but as deadly as bubonic plague.

Imagine a strain of an entirely new pathogen that is extremely lethal and completely immune to all modern medicine.

These are all possible, albeit exceedingly difficult, with genetic editing. Unlike nuclear weapons, it doesn’t require the procurement of expensive and dangerous elements. It just needs DNA, RNA, and a lab with which to produce them. It’s a scary idea, but that’s actually not the worst of it, nor is it the one that worries me most.

A doomsday bioweapon like that might be appealing to generic super-villains, but like nuclear weapons, they’re not very strategic because they kill everyone and everything. For those with a more strategic form of blood-lust, advanced biological weapons offer advantages that sets them apart from any other weapon.

Instead of a pathogen infecting everyone it comes into contact with, what if it only infected a certain group of people that carry a specifics traits associated with a particular race or ethnic group? What if someone wanted to be even more strategic than that and craft a pathogen that attacked only one specific person?

In principle, this is possible if you can manipulate the genetics of a disease in just the right way. Granted, it’s extremely difficult, but the potential utility makes it more useful than a nuclear bomb will ever be.

Suddenly, a government or terrorist organization doesn’t need a skilled assassin on the level of James Bond to target a specific person or group. They just need the right genetic material and a working knowledge of how to program it into a synthetic pathogen. It could even be made to look like a completely different disease, which ensured it didn’t raise any red flags.

It’s not the ultimate weapon, but it’s pretty darn close. Biological weapons with this level of refinement could potentially target entire groups of people and never put the attackers at risk. As a strategy, it can effectively end an entire conflict without a shot being fired. Those infected wouldn’t even know it was fired if the pathogen were effectively distributed.

It’s one of those weapons that both terrorists and governments would be tempted to use. The most distressing part is they could use it in a way that’s difficult to detect, let alone counter. Even after all the death and destruction has been wrought, how do you even prove that it was a result of a bioweapon? Even if you could prove that, how would you know who made it?

These are the kinds of questions that only have disturbing answers. They’re also the reasons why I believe biological weapons are poised to become a far bigger issue in the coming years. Even if it’s unlikely they’ll wipe out the human race, they can still cause a special kind of destruction that’s almost impossible to counter.

Unlike any other weapon, though, the destruction could be targeted, undetectable, and unstoppable. Those who wield this technology would have the power to spread death with a level of precision and tact unprecedented in human history. While I believe that humanity will eventually be able to handle dangerous technology like artificial intelligence, I doubt it’ll ever be capable of handling a weapon like that.

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When Sex Is Divorced From Reproduction: The Possibilities And Implications

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Relatively speaking, it wasn’t that long ago in humanity’s history when finding food was a matter of survival. It wasn’t as simple as walking into the nearest grocery store and buying whatever was on sale. Individuals, governments, and societies dedicated a good chunk of their time and energy into securing a stable food source. Those who didn’t were usually the first victims of the next famine.

These days, getting a meal is less about survival and more about logistics. Thanks to major advances in agricultural science, including those of the late Norman Borlaug, we have so much abundant food that overeating is now a bigger problem than famine. Hunger is still a major issue for certain parts of the world, but it’s more a logistical issue than a resource issue.

Once food was divorced from famine and survival, it changed the way society approached it. Most people don’t even think about where they’re going to get their next meal. Their main concern is whether it’ll be a tasty meal.

With this critical need met, we can focus more time and energy on other matters. Even before science gave us abundant food, sex and reproduction was usually our second most pressing focus. It’s the other powerful drive that unites us all as a species. As a result, it’s subject to all sorts of taboos and has been central to multiple revolutions.

There’s no question that technology has impacted sexuality every bit as much as it impacted food production. Even advances unrelated to sex, especially anti-biotics, affected various attitudes and norms. However, even with these advances, sex maintains much of its primary function in that it’s still necessary for reproduction.

With that in mind, what happens when that’s no longer the case?

What happens to sex when it’s completely divorced from reproduction?

This isn’t another speculative thought experiment. This process is already unfolding. I would argue that it started on July 25, 1978 when the first baby was born from in vitro fertilization. Since then, over 8 million babies have been born through this technology. That is not a trivial number when we’re dealing with human lives.

Just take a step back to appreciate the implications of these lives. They were all conceived and birthed without sex. In centuries past, this was grounds for a miracle that could serve as a basis for a major religion. These days, it’s so routine that it never makes the news. Most people don’t think about it. It helps that these people are just as healthy and prosperous as those who were conceived with sex.

In the near future, this could change as well. Late last year, our technology went a step further beyond conceiving babies through in vitro fertilization with the birth of the first genetically edited babies in China. Now, it’s not just normal babies being born through this technology. Thanks to tools like CRISPR, children born without sex could be healthier and stronger than those conceived through sex.

Again, that is not a trivial detail. It’s one thing for technology to simply match a natural process, especially one as critical as human reproduction. Once it starts doing it better than nature, then that’s a huge paradigm shift. It might even be a point of no return. Having babies through sex is still a thing, but it’s no longer the most effective way to have healthy, strong children.

While this has generated plenty of controversy around topics like designer babies, there hasn’t been as much discussion about what this means for sex. If sex is no longer the primary method for reproduction, or the safest for that matter, what happens to our society? What happens to centuries of taboos, attitudes, traditions, and gender roles?

It’s difficult to speculate, but some have tried. In a recent article with the BBC, author Henry T. Greely laid out a general timeline. It doesn’t rely entirely on huge leaps in reproductive technology. It simply follows the trends that began with in vitro fertilization. In the interview, these are just a few thoughts he shared.

In 20 to 40 years, most people all over the world with good health coverage will choose to conceive in a lab. Like most things, there will be a fair amount of visceral negative reaction initially, but as time goes on and kids prove not to have two heads and a tail, the public will come not only to tolerate but to prefer reproducing non-sexually.

From a logistic and public health standpoint, this makes sense. Any healthy and prosperous society would want to promote the birth of healthy children in a manner that preserves the health of the mother. With technology like in vitro and CRISPR, it might very well be preferable because it means fewer diseases, lower health care costs, and fewer burdens on parents.

That doesn’t even begin to factor in the impact of more advanced reproductive technologies. With advances like artificial wombs in development, sex wouldn’t just be divorced from reproduction. Reproduction might not require any intimate connection whatsoever. At that point, sex for reproduction is akin to drinking unpasteurized milk.

Will people still have sex at that point? I believe they will. Unless we radically change our bodies all at once, the hardware for sex will still be present. The drive to do it will still be there as well, although some might opt to turn it off if that were an option. Regardless of any lingering attitudes and taboos, there’s no getting around it. Sex still feels good. It’s still a profoundly intimate act with many health benefits.

How people go about it will likely change. A great many taboos about sex stem from its role in reproduction. Much of the stigma surrounding promiscuity and traditional gender roles have a basis in highlighting the importance of sex in the propagation of our society and species. If are reckless about it, then that can spread disease, destabilize families, and create unhealthy environments for children.

Going back to the parallels with food, the same logic was once used to discourage gluttony. For much of human history, we had to be careful with how we consumed our food. If people consumed too much and were reckless with our eating habits, then they were ill-prepared for the next famine that inevitably came.

While sex and reproduction are still very different from consuming food, the influence of technology had a major impact on collective attitudes. We don’t look at people who overeat the same way we look at people who have lots of sex. Both may still draw scorn, but few will worry for the survival of the future of their community if a handful of people overeat.

At the moment, there are very real concerns surrounding falling birth rates and people having less sex than ever before. In some countries, the low birth rates are seen as an outright crisis that has also fueled ongoing debates surrounding immigration. Crisis or not, this situation is adding more urgency to the development of reproductive technologies. That, along with the decline in sex, could hasten this pending divorce.

Once it’s finalized, what form will sex take? It could simply become an act of intimacy or recreation. Humans might ultimately treat it the same way Bonobo monkeys treat it. It’s just an intimate activity that people do. Reproduction never even enters the conversation. People save that for when they want to design their baby.

It could also gain another purpose entirely. Maybe sex becomes less an act of intimacy and more an elaborate handshake, of sorts. It could be seen as a way of establishing trust or differentiating between casual acquaintances and close friends. In that world, friends with benefits are just friends. The benefits are implied by the friendship.

There’s also the very real possibility that people will just lose interest in sex. If there’s no reason to do it and it has no bearing on the growth of a society, then it just might be an afterthought. People might still do it, but those who do would be like the people who still have their own gardens in the backyard. It’s a quaint echo of our past that most have moved past.

These are possibilities. For now, there are no inevitabilities with respect to how we’ll approach sex once it’s no longer necessary for reproduction. It’ll likely be several decades before reproductive technology gets to a point where it’s preferable to sex, both for individuals and societies at large. Until then, this lengthy divorce is already at the early stages. It’s just a matter of how messy it’ll get in the coming years.

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